Effects of apolipoprotein A5 haplotypes on the ratio of triglyceride to high-density lipoprotein cholesterol and the risk for metabolic syndrome in Koreans

Table 2 Association of haplotypes in APOA5 and ZNF259 gene regions with log[TG]:HDL-C ratio

Subject	Hap 1 & 2	11/12/22 [n]	11/12/22 [mean (sd)]	Effect (95% CI)*	P*
All	ht1, ht2	1,398/838/115	0.0448 (0.0145)/0.0471 (0.0155)/0.0509 (0.0165)	0.00222 (0.00130 - 0.00315)	2.68E-06
	ht1, ht3	1,398/340/17	0.0448 (0.0145)/0.0491 (0.0173)/0.0587 (0.0154)	0.00460 (0.00313 - 0.00607)	1.05E-09
	ht2, ht3	115/123/17	0.0509 (0.0165)/0.0537 (0.0180)/0.0587 (0.0154)	0.00289 (-0.000221 - 0.00599)	0.0686
Men	ht1, ht2	482/325/42	0.0508 (0.0155)/0.0528 (0.0156)/0.0609 (0.0159)	0.00328 (0.00154 - 0.00502)	2.25E-04
	ht1, ht3	482/124/5	0.0508 (0.0155)/0.0567 (0.0176)/0.0590 (0.0125)	0.00606 (0.00324 - 0.00888)	2.83E-05
	ht2, ht3	42/54/5	0.0609 (0.0159)/0.0605 (0.0194)/0.0590 (0.0125)	0.00122 (-0.00486 - 0.00731)	0.690
Women	ht1, ht2	916/513/73	0.0417 (0.0128)/0.0435 (0.0143)/0.0452 (0.0140)	0.00157 (0.000507 - 0.00264)	3.84E-03
	ht1, ht3	916/216/12	0.0417 (0.0128)/0.0447 (0.0156)/0.0585 (0.0170)	0.00391 (0.00223 - 0.00558)	5.20E-06
	ht2, ht3	73/69/12	0.0452 (0.0140)/0.0484 (0.0150)/0.0585 (0.0170)	0.00473 (0.00130 - 0.00816)	7.16E-03

*The effect (beta), 95% confidence interval (CI), and p-value for Hap 2 versus Hap 1 were estimated by linear regression, after adjusting for age, sex (in all subjects), physical activity (three categories), daily food intake (three categories), clinical history, and medications for hypertension, dyslipidemia, and/or diabetes.

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