Table 1 Baseline characteristics and results
From: Altered sphingoid base profiles in type 1 compared to type 2 diabetes
Type 1 | Type 2 | Control | overall p-value | T1 vs. T2 p-value | T2 vs. control p-value | T1 vs. control p-value | |
|---|---|---|---|---|---|---|---|
N | 27 | 30 | 23 | Kruskal-Wallis/Chi-Sq | Wilcoxon/Fisher’s | Wilcoxon/Fisher’s | Wilcoxon/Fisher’s |
Age, mean (s.d.) | 47 (14.6) | 60 (13.6) | 43 (15) | <0.001 | 0.001 | <0.001 | 0.4 |
Male, N (%) | 16 (59) | 16 (53) | 11 (48) | 0.7 | 0.8 | 0.8 | 0.6 |
HbA1c, mean (s.d.) | 7.3 (1.3) | 7.8 (2) | 5.2 (0.3) | <0.001 | 0.4 | <0.001 | <0.001 |
TG, mean (s.d.) | 70 (33) | 145 (84) | 84 (35) | <0.001 | <0.001 | 0.003 | 0.1 |
LDL, mean (s.d.) | 87 (27) | 83 (35) | 116 (44) | 0.006 | 0.8 | 0.008 | 0.006 |
HDL, mean (s.d.) | 70 (17) | 49 (22) | 60 (19) | <0.001 | <0.001 | 0.02 | 0.04 |
HTN, N (%) | 14 (52) | 25 (83) | 3 (13) | <0.001 | 0.02 | <0.001 | 0.006 |
SBP, mean (s.d.) | 124 (15) | 130 (15) | 125 (17) | 0.2 | 0.08 | 0.3 | 0.8 |
DBP, mean (s.d.) | 72 (8) | 74 (8) | 76 (12) | 0.4 | 0.4 | 0.7 | 0.2 |
Cr, mean (s.d.) | 0.97 (0.4) | 0.90 (0.2) | 0.91 (0.5) | 0.2 | 0.7 | 0.2 | 0.07 |
Statin, N (%) | 14 (52) | 23 (77) | 2 (9) | <0.001 | 0.06 | <0.001 | 0.002 |
DM duration, mean (s.d.) | 25 (11) | 13 (8) | 0 | <0.001 | |||
C16SO, mean (s.d.) | 16.9 (4.4) | 18.4 (6.0) | 19.9 (9.5) | 0.8 | 0.5 | 0.99 | 0.6 |
C16SA, mean (s.d.) | 0.26 (0.13) | 0.41 (0.19) | 0.45 (0.22) | <0.001 | <0.001 | 0.6 | 0.001 |
C17SO, mean (s.d.) | 7.1 (1.6) | 7.4 (2.3) | 8.5 (3.3) | 0.5 | 0.8 | 0.4 | 0.3 |
C18SAdiene, mean (s.d.) | 34.9 (6.4) | 30.3 (9.3) | 39.3 (11.3) | 0.007 | 0.02 | 0.006 | 0.3 |
C18SO, mean (s.d.) | 92.3 (11.2) | 87.1 (20.4) | 103.9 (25.4) | 0.02 | 0.1 | 0.01 | 0.1 |
C18SA, mean (s.d.) | 3.1 (1.0) | 2.4 (0.6) | 2.9 (1.0) | 0.01 | 0.03 | 0.3 | 0.008 |
C20SO, mean (s.d.) | 0.13 (0.02) | 0.15 (0.05) | 0.14 (0.04) | 0.2 | 0.06 | 0.2 | 0.8 |
C20SA, mean (s.d.) | 0.02 (0.004) | 0.02 (0.01) | 0.02 (0.002) | 0.02 | 0.004 | 0.3 | 0.1 |
doxSA, mean (s.d.) | 0.05 (0.02) | 0.09 (0.06) | 0.05 (0.02) | <0.001 | <0.001 | <0.001 | 0.5 |
doxSO, mean (s.d.) | 0.12 (0.04) | 0.19 (0.11) | 0.12 (0.04) | 0.002 | 0.002 | 0.006 | 0.9 |