Genetic association of APOB polymorphisms with variation in serum lipid profile among the Kuwait population

Table 3 Genotype and allele frequencies of the five APOB polymorphisms analyzed (n = 795)

Polymorphism	Genotype			Allele		HWE	Heterozygosity estimate
SP (rs11279109)	II	ID	DD	I	D	p = 0.638	0.33
n	483	265	47	0.77	0.23
(%)/f	60.75	33.33	5.91	0.77	0.23
VNTR	MM	ML	LL	M	L	p = 0.013	0.15
n	655	116	24	0.90	0.10
(%)/f	82.39	14.59	3.02	0.90	0.10
Xba1 (rs693)	X ⁻ X ⁻	X ⁺ X ⁻	X ⁺ X ⁺	X ⁻	X ⁺	p = 0.717	0.39
n	430	308	57	0.73	0.27
(%)/f	54.09	38.74	7.17	0.73	0.27
Msp1 (rs1801701)	M ⁺ M ⁺	M ⁺ M ⁻	M ⁻ M ⁻	M ⁺	M ⁻	p = 0.599	0.12
n	692	99	4	0.93	0.07
(%)/f	87.04	12.45	0.50	0.93	0.07
EcoR1 (rs1042031)	E ⁺ E ⁺	E ⁺ E ⁻	E ⁻ E ⁻	E ⁺	E ⁻	p = 0.211	0.18
n	640	142	13	0.89	0.11
(%)/f	80.50	17.86	1.64	0.89	0.11

The table summarizes the genotypes for the signal peptide (SP) (rs11279109), variable number of tandem repeats (3’VNTR), Codons 2488-XbaI C(X⁻) < T(X⁺) (rs693), 3611-MspI G(M⁻) < A(M⁺) (rs1801701) and 4154-EcoRI G(E⁻) < A(E⁺) (rs1042031).
n: number of samples, f: allele frequency HWE: Hardy-Weinberg Equilibrium with significant p- value level at 0.05.

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