Lipids in Health and Disease

Table 5 The distubution of haplotype in CAD patient and control participants

From: Diplotypes of CYP2C9 gene is associated with coronary artery disease in the Xinjiang Han population for women in China

			Total					Men				Women
			CAD (%)	Control (%)	Nominal p	Adjusted p	CAD (%)	Control (%)	Nominal p	Adjusted p	CAD (%)	Control (%)	Nominal p	Adjusted p
1	0100	CTAC	34.02	37.16	0.2699	0.6747	38.09	34.7	0.2299	0.3831	26.02	41.38	0.0032*	0.016*
2	0000	CCAC	34.47	35.16	0.7979	0.9973	31.87	31.41	0.3916	0.3916	39	40.04	0.3360	0.4200
3	1000	TCAC	2.5	2.48	0.9727	0.9727	1.55	3.04	0.1537	0.3074	4.43	1.73	0.0761	0.1900
4	1100	TTAC	1.22	ˉ	0.0221	0.2210	1.06	ˉ	0.1472	0.3680	1.55	ˉ	0.0902	0.1503
5	0010	CCCC	5.4	4.3	0.4255	0.8510	5.83	6.08	0.3707	0.4119	4.41	1.41	0.0634	0.1133
6	1010	TCCC	2.27	2.34	0.9226	1.0000	2.28	2.89	0.3394	0.4243	2.34	2.02	0.3537	0.3537
7	0110	CTCC	3.9	1.52	0.0300	0.1500	3.75	1.25	0.1020	0.5100	4.06	1.18	0.0877	0.1754
8	0001	CCAT	10.05	9.18	0.5749	0.8212	8.16	13.3	0.1000	1.0000	13.15	3.04	0.0016*	0.016*
9	1001	TCAT	2.49	3.12	0.5333	0.8888	3.88	2.7	0.2834	0.4049	0	3.72	-	-
10	0101	CTAT	0	2.23	-	-	0	1.36	-	-	1.74	3.18	0.1573	0.2242
11	1101	TTAT	2.25	0	-	-	2.08	0	-	-	1.98	0	-	-
12	0011	CCCT	1.43	2.52	0.1746		1.47	3.27	0.1230	0.4100	1.31	1.05	0.3476	0.3862
13	1011	TCCT	-	-	-	-	-	-	-	-	0	1.26	-	-

The p value of haplotype was calculated by Fisher's exact test, and revised by False discovery rate. ^* p>0.05;
‘0 represents major allele’ and 1 represents minor allele’.
“0100” refers respectively the major allele of the SNP1,minor allele of the SNP2,major allele of the SNP3,major allele of the SNP4.
The p value of each haplotype by the order of SNP1-SNP2-SNP3-SNP4 is relative to the other haplotypes as a group (overall p <0.0001).

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ISSN: 1476-511X

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