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Table 2 Significant alterations in body weight, insulin level, lymphocyte counts, and levels of free radicals in offspring at 8 weeks of age

From: Maternal supplementation of diabetic mice with thymoquinone protects their offspring from abnormal obesity and diabetes by modulating their lipid profile and free radical production and restoring lymphocyte proliferation via PI3K/AKT signaling

Parameters

Offspring of control dams

Offspring of diabetic dams

Offspring of diabetic dams supplemented with TQ

At birth

Body weight (g)

1.24 ± 0.1

1.89 ± 0.1*

1.39 ± 0.11#

At age of 8 weeks

body weight (g)

20 ± 1.9

28.9 ± 2.9*

23.3 ± 2.3

Blood glucose (mg/dl)

141 ± 12

218 ± 19.5*

178.5 ± 13.4#+

Insulin (ng/ml)

2.4 ± 0.1

1.52 ± 0.15*

2.1 ± 0.19#

WBCs count (103/ul)

15 ± 0.9

11 ± 0.1*

13.5 ± 0.18#

Lymphocytes (%)

75 ± 5.8

58 ± 4.8*

71.6 ± 0.18#

Monocytes (%)

5 ± 0.18

4 ± 0.35

5 ± 0.6

Neutrophils (%)

20 ± 1.45

19 ± 1.3

21 ± 1.95

ROS (nmol/ml)

11 ± 1.9

25 ± 3.9*

17 ± 2.1#+

Hydroperoxide (mg/100 ml)

17 ± 2.7

34 ± 4.4*

24 ± 2.8#+

  1. The results are expressed as the mean ± SEM. *P < 0.05 for diabetic vs. control; #P < 0.05 for diabetic + TQ vs. diabetic; +P < 0.05 for diabetic + TQ vs. control.