Figure 5
Effect of peroxisome proliferators activated receptor alpha (PPARα ) induction on hepatic expression of profibrotic factors. (A1) Expression level of osteopontin (OPN) mRNA and (A2) protein; (B1) Expression level of transforming growth factor-beta 1 (TGF-β1) mRNA and (B2) protein; (C1) Expression level of visfatin mRNA and (C2) protein; (D1) Expression level of phosphatidylinositol 3-kinase (PI3K) mRNA and (D2) protein; (E1) Expression level of matrix metalloproteinase-2 (MMP-2) mRNA and (E2) protein; (F1) Expression level of MMP-9 mRNA and (F2) protein in various treatment groups. *P<0.05, **P<0.01, ***P<0.001, vs. control group; #P<0.05, ##P<0.01, vs. ethanol group; $P<0.01, $$P<0.001, vs. ethanol+CCl4 group. CCl4, ccarbon tetrachloride; WY, WY14643.