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Table 3 LPP1 related gene expression in human skeletal muscle

From: Identification of hemostatic genes expressed in human and rat leg muscles and a novel gene (LPP1/PAP2A) suppressed during prolonged physical inactivity (sitting)

GENE

Access #

Expression

Frequency

P-value

Function

GENE SUPPRESSED BY PHYSICAL INACTIVITY

LPP1

AB000888.1

Strong detection

8/8

0.004

Dephosphorylates LPA, S1P, PA, ceramide-1-P

GENES NOT AFFECTED BY PHYSICAL INACTIVITY

LPP2

AF047760.1

Not detected

0/8

0.47

Dephosphorylates LPA, S1P, PA, ceramide-1-P

LPP3

NM_003713

Strong detection

8/8

0.0007

Dephosphorylates LPA, S1P, PA, ceramide-1-P

8/8

0.0002

LPAP

AB031478.1

Moderate detection

2/8

0.068

Dephosphorylates LPA

SGPP1

NM_030791

Moderate detection

7/8

0.024

Dephosphorylates S1P

SGPL1

NM_003901.1

Not detected

0/8

0.90

Irreversible sphingosine 1-phosphate degradation

SPHK1

NM_021972.1

Not detected

0/8

0.19

Phosphorylates sphingosine

AGPAT1

U56417

Strong detection

8/8

0.0029

ER enzyme converting LPA to PA

8/8

0.0056

AGPAT2

U56418

Moderate detection

8/8

0.028

ER enzyme converting LPA to PA

AGPAT3

NM_020132

Strong detection

8/8

0.002

ER enzyme converting LPA to PA

AGPAT4

NM_020133.1

Not detected

0/8

0.25

Converts LPA to PA

LYPLA1

AF077198.1

Strong detection

8/8

0.0002

Hydrolyzes lysophosphatidylcholine to LPA

LYPLA2

NM_007260.1

Strong detection

8/8

0.014

Hydrolyzes lysophosphatidylcholine to LPA

EDG2

45580697

Moderate detection

4/8

0.068

LPA receptor

EDG3

NM_005226

Not detected

0/8

0.43

LPA receptor

EDG4

NM_004720.3

Not detected

0/8

0.63

LPA receptor

EDG7

NM_012152.1

Not detected

0/8

0.33

LPA receptor

EDG8

AF317676

Not detected

0/8

0.97

S-1-P receptor

P2Y9

NM_005296.1

Not detected

0/8

0.63

LPA receptor, platelet

ROCK2

D87931

Strong detection

7/8

0.010

LPA activated kinase

  1. Access # is NCBI accession number. Frequency is the number of biopsy samples showing significant expression out of a total number of 8 biopsies. P-value is the median p-value of a Wilcoxon test for all 8 human biopsy samples. The gene was bolded and the p-value was underlined if it met the FDR criteria for being significantly detected. Multiple probe sets are available for some genes and are presented in the Table. ER, endoplasmic reticulum; LPA, lysophosphatidic acid; S1P, sphingosine-1-phosphate; PA, phosphatidic acid LPA, lysophosphatidic acid; S1P, sphingosine-1-phosphate; PA, phosphatidic acid; AGPAT, 1-acylglycerol-3-phosphate acyltransferase; EDG, endothelial differentiation gene; LPAP, LPA phosphatase; LPP, lipid phosphate phosphatase; LYPLA, lysophospholipase; ROCK2, Rho-associated, coiled-coil containing protein kinase 2; SGPL1, sphingosine-1-phosphate lyase 1; SGPP1, sphingosine-1-phosphatase; SPHK1, sphingosine kinase 1.