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Figure 2 | Lipids in Health and Disease

Figure 2

From: Regulation of adipocyte autophagy — The potential anti-obesity mechanism of high density lipoprotein and ApolipoproteinA-I

Figure 2

Effect of HDL/apoA-I on autophagy in preadipocyte. HDL/apoA-I activated PI3K-Akt signaling pathway through SR-BI dependent mechanism and/or S1P of HDL binding to S1P receptor. Activated Akt positively regulated the activity of mTORC1 with consequent autophagy inhibition. apoA-I, apolipoprotein A-I; HDL, high density lipoprotein; PI3K, phosphatidylinositol 3-kinase; S1P, sphingosine-1-phosphate.

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